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Research Progress of DBU in C─C, C-Heteroatom, and Heteroatom-Heteroatom Bond Formations
Ravi Varala1,2, Murali Mohan Achari Kamsali3, Hari Babu Bollikolla4
1Scrips Pharma, Mallapur, Hyderabad, Telangana, India.
None:
1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU), a commercially available and easily handled bicyclic amidine base, is recognized as a strong organic base and deprotonating agent with nucleophilic properties, which has become increasingly important in organic synthesis in recent years. The selectivity of this reagent, including chemo-, regio-, and stereo-selectivity, is exceptionally high and highly applicable in modern synthetic organic transformations. This review article offers a succinct update on various types of C─C, C-heteroatom, and heteroatom-heteroatom bond formation reactions. It highlights representative methodologies employing DBU as a catalyst, base, or reactant, covering developments from May 2022 to the present (triennial update). The compilation is systematically organized into categories including C─C, C-heteroatom, heteroatom-heteroatom bond formation, and reactions involving multiple bonds, primarily. Furthermore, various additional reactions, including isomerization, rearrangement, and the formation of heterocyclic rings, facilitated by DBU, have also been recorded.
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