Design of a Mobile App and a Clinical Trial Management System for Cognitive Health and Dementia Risk Reduction:...

Area of Science:

• Gerontology
• Digital Health
• Cognitive Neuroscience

Background:

• Dementia prevalence is increasing, with a significant portion linked to modifiable risk factors.
• The LETHE project focuses on a personalized digital intervention to mitigate cognitive decline risks.

Purpose of the Study:

• To design a clinical trial platform for older adults at risk of cognitive decline.
• To develop a mobile application for participants and a clinical trial management system (CTMS) for health professionals.

Main Methods:

• User-centered design with workshops and feedback from target users and professionals.
• Usability assessment of the LETHE app via the System Usability Scale (SUS) in a multinational randomized controlled trial.
• Feedback collection on the LETHE CTMS from health professionals.

Main Results:

• High response rates for the LETHE app (85% in intervention group) with median SUS scores of 70 and 73.
• Positive feedback received for the CTMS, with 71% response rate.
• Personalized activities and real-time appointments identified as highly novel features.

Conclusions:

• The LETHE app and CTMS support personalized digital interventions for cognitive decline prevention.
• Positive usability and feedback suggest potential for LETHE tools in older adults.
• Digital literacy and internet access are limitations affecting generalizability.