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Kinetic Monitoring of in vitro Release Testing Using UV-Vis Spectrophotometry with Hydrocortisone Creams

Kelsey Leach1, Lola Sibaud1, Bradley Towey1

  • 1Chemistry and Biochemistry, Minnesota State University Moorhead, Moorhead, Minnesota, USA.

Skin Pharmacology and Physiology
|July 2, 2025
PubMed
Summary

A new UV-Vis spectrophotometry method for in vitro release testing (IVRT) of hydrocortisone formulations is validated. This rapid IVRT method offers a reliable alternative for semisolid drug release analysis.

Keywords:
Abbreviated new drug applicationsHydrocortisoneIn vitro release testingKinetic monitoringUV-Vis

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