Related Experiment Video
Updated: Sep 17, 2025

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
Characteristics and Trends in Child Cannabis Exposures During Legalization in California
Laura A Schmidt1, Laurie M Jacobs2, Ellicott C Matthay3
1Philip R. Lee Institute for Health Policy Studies, School of Medicine, University of California San Francisco, San Francisco, California; Department of Humanities and Social Sciences, School of Medicine, University of California San Francisco, San Francisco, California.
Introduction:
In 2016, California legalized cannabis for adult recreational use; after recreational sales began in 2018, it became the largest retail market worldwide. This study profiled specific risks and prevention opportunities across age groups and examined changes in medically significant child cannabis exposures before and after legalization.
Methods:
Researchers conducted analyses, including interrupted time series, to examine 1,695 California Poison Control System reports of cannabis exposure in children aged 0-17 years from 2010 to 2020. Analyses were confined to moderate and severe exposures, identified by California Poison Control System toxicologists as requiring medical attention.
Results:
Monthly rates of moderate/severe cannabis exposure per million children increased after legalization (β=0.06; 95% CI=0.05, 0.08), especially in children aged <5 years. Fourteen percent required critical care admission. Exposures were primarily unintentional in younger children (87.7%-99.2%) and intentional in adolescents (85.5%). Across all ages, most exposures occurred in the home (94.0%) and involved edible products (83.5%). An analysis of packaging on edible brands frequently cited in health records found that most could be easily mistaken for popular candies and snack foods.
Conclusions:
After cannabis legalization in California, reports of child cannabis exposures requiring medical attention increased significantly. Most reported cannabis exposures occurred in the home through the ingestion of edible products, often packaged to look like popular candy and snack food brands. To prevent these harms, cannabis legalization should be accompanied by robust marketing and packaging regulations (e.g., plain labels, larger warning labels). Secondary prevention should focus on educating parents and caregivers on safe cannabis storage in the home.
Related Concept Videos
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
An Overview of Psychoactive Drugs
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Hallucinogens and Psychedelics
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Altered States of Awareness
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
Drug Abuse and Addiction: Pharmacological Phenomena

