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Microbial Biosensors01:17

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
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Aptamer-based biosensors for troponin detection.

Suleiman Ibrahim Mohammad1, Hamza Abu Owida2, Badrea Al Oraini3

  • 1Electronic Marketing and Social Media, Economic and Administrative Sciences Zarqa University, Jordan; INTI International University, 71800 Negeri Sembilan, Malaysia.

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Cardiac troponin aptasensors offer sensitive detection of myocardial infarction. This review highlights recent advancements in aptasensor technologies for rapid point-of-care cardiac troponin determination.

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Cardiovascular Diagnostics

Background:

  • Cardiac troponin is a key biomarker for acute myocardial infarction (AMI) detection.
  • Biosensors offer rapid, point-of-care alternatives to traditional diagnostic methods.
  • Aptamers are emerging as effective alternatives to antibodies in biosensing applications.

Purpose of the Study:

  • To provide a comprehensive overview of recent advancements in aptamer-based biosensors (aptasensors) for cardiac troponin detection.
  • To explore various aptasensor platforms for sensitive and accessible cardiac troponin determination.
  • To highlight the potential of aptasensors in early diagnosis of acute myocardial infarction.

Main Methods:

  • Review of recent literature on aptasensor development for cardiac troponin.
  • Categorization of aptasensors based on detection principles (fluorescence, SPR, colorimetric, SERS, electrochemical, LFA).
  • Analysis of sensitivity, accessibility, and point-of-care capabilities of different aptasensor types.

Main Results:

  • Significant progress in developing diverse aptasensor platforms for cardiac troponin.
  • Demonstrated high sensitivity and accessibility of aptasensors for biomarker detection.
  • Various aptasensor formats show promise for rapid, point-of-care diagnostics.

Conclusions:

  • Aptasensors represent a promising technology for the early and sensitive detection of cardiac troponin.
  • Advancements in aptasensor design facilitate accessible point-of-care diagnostics for acute myocardial infarction.
  • Continued research in aptasensor technology will further enhance cardiovascular diagnostics.