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Updated: Sep 17, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Programmable Liposome Organization via DNA Origami Templates.

Zhao Zhang¹, Zhaomeng Feng^1,2, Xiaowei Zhao³

¹Howard Hughes Medical Institute, Department of Neuroscience, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.

Journal of the American Chemical Society

|July 2, 2025

Summary

This summary is machine-generated.

Researchers developed a DNA origami platform to precisely arrange liposomes, enabling custom 2D arrays and dynamic structures. This innovation advances drug delivery and nanotechnology applications.

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Last Updated: Sep 17, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

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Published on: December 3, 2015

Designing a Bio-responsive Robot from DNA Origami

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Published on: July 8, 2013

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

Area of Science:

Biotechnology
Nanotechnology
Synthetic Biology

Background:

Liposomes are crucial for drug delivery and membrane protein studies.
Current methods lack precise control over liposome organization, limiting applications.

Purpose of the Study:

To present a novel DNA origami platform for templating liposome formation and organization.
To enable precise control over liposome arrangement in 2D arrays, lattices, and rings.

Main Methods:

Utilizing square DNA origami with programmable sticky ends.
Templating the assembly of uniformly sized liposomes into defined architectures.
Demonstrating stepwise assembly and targeted disassembly for dynamic control.

Main Results:

Successful formation of diverse 2D liposome arrays, lattices, and rings.
Achieved precise control over liposome size, number, position, and chirality.
Demonstrated dynamic structural control through stepwise assembly and disassembly.

Conclusions:

The DNA origami platform offers unprecedented control over liposome organization.
This technology opens new avenues for advanced drug delivery systems and bottom-up nanotechnology.
Enables the creation of complex, functional liposome architectures for various scientific fields.