Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypertension I: Introduction

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...

Factors affecting Blood pressure

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:

Hypertension II: Pathophysiology

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...

Hypertension and Regulation of Blood Pressure

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...

Search research articles

Home
Cumulative Effect Of Pm2.5 Chemical Components Surpasses Pm2.5 Mass On Hypertension In Older Adults: A China-based National Analysis

Home
Cumulative Effect Of Pm2.5 Chemical Components Surpasses Pm2.5 Mass On Hypertension In Older Adults: A China-based National Analysis

Related Experiment Video

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

Cumulative effect of PM_2.5 chemical components surpasses PM_2.5 mass on hypertension in older adults: A China-based

Chen Chen¹, Binbin Su², Yunhe Wang³

¹Department of Population health and Aging science, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Journal of Environmental Sciences (China)

|July 2, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Fine particulate matter (PM2.5) chemical components, especially nitrate, significantly increase hypertension risk in older adults. Targeting specific PM2.5 constituents, not just total mass, is crucial for effective public health interventions.

Keywords:

Aging Ambient air pollution Hypertension PM(2.5) chemical components

More Related Videos

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter

A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter

Published on: June 13, 2025

Related Experiment Videos

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Measuring Carbon Content in Airway Macrophages Exposed to Carbon-Containing Particulate Matters

Published on: July 12, 2024

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter

A Modified QuEChERS-HPLC Method for Detection of Polycyclic Aromatic Hydrocarbons in Zebrafish Embryos Exposed to Fine Particulate Matter

Published on: June 13, 2025

Area of Science:

Environmental Health
Cardiovascular Epidemiology
Toxicology

Background:

Hypertension is a major global health concern, particularly among aging populations.
The precise impact of specific fine particulate matter (PM2.5) components on hypertension is not fully understood.
Older adults represent a vulnerable group susceptible to air pollution-related health issues.

Purpose of the Study:

To investigate the individual and combined effects of PM2.5 chemical components on hypertension prevalence in Chinese older adults.
To quantify the population attributable fractions (PAFs) for hypertension linked to PM2.5 constituents.
To assess whether total PM2.5 mass adequately represents the health risks posed by its components.

Main Methods:

Utilized a national dataset of 220,425 older adults in China.

Estimated residential PM2.5 and five chemical components (BC, OM, SO42-, NO3-, NH4+) using bilinear interpolation.

Employed two-stage logistic regression and counterfactual analysis to determine associations and PAFs.

Main Results:

Elevated exposure to PM2.5 components was associated with increased hypertension prevalence.
Nitrate (NO3-) showed the highest odds ratio for hypertension (OR: 1.09), followed by ammonium (NH4+), organic matter (OM), sulfate (SO42-), and black carbon (BC).
The cumulative effect of PM2.5 components (OR: 1.13) exceeded that of total PM2.5 mass (OR: 1.04), with nitrate contributing most significantly to hypertension.

Conclusions:

Specific PM2.5 chemical components have distinct and significant impacts on hypertension risk in older adults.
Total PM2.5 mass may underestimate the health burden, highlighting the importance of analyzing individual constituents.
Targeted reduction strategies for specific PM2.5 components, particularly nitrate, are necessary for mitigating hypertension in vulnerable populations, especially those with lower socioeconomic status.