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Published on: August 7, 2017
Association between the DASH diet and Alzheimer's disease in a case-control study
Mohammad Mehdi Abbasi1, Sajjad Khandae1, Mahshad Shahabi1
1Student Research Committee, Department, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Adhering to the Dietary Approaches to Stop Hypertension (DASH) diet may lower Alzheimer's disease risk. This study found significant associations between higher DASH diet adherence and reduced disease risk in the Middle East.
Area of Science:
- Neuroscience
- Nutritional Science
- Epidemiology
Background:
- Inconsistent findings exist regarding the link between Alzheimer's disease (AD) and the DASH diet.
- The association between AD and the DASH diet remains underexplored in the Middle East.
Purpose of the Study:
- To investigate the association between adherence to the DASH diet and the risk of developing Alzheimer's disease.
Main Methods:
- A case-control study was conducted with 212 participants (106 AD cases, 106 controls) in Tehran.
- Dietary intake was assessed using a 168-item food frequency questionnaire.
- Four DASH diet indices (Dixon, Mellen, Fung, Günther) were utilized to measure adherence.
Main Results:
- Higher adherence to Mellen's, Fung's, and Günther's DASH diet indices was significantly associated with a reduced risk of Alzheimer's disease.
- Odds ratios (OR) for reduced AD risk were observed for Mellen's (OR: 0.29), Fung's (OR: 0.22), and Günther's (OR: 0.36) indices.
- These associations remained significant after adjusting for potential confounding factors.
Conclusions:
- Adherence to the DASH dietary pattern may be associated with a decreased risk of Alzheimer's disease.
- Further prospective studies are recommended to confirm these findings in the Middle East population.
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