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Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
Advanced preclinical functional magnetic resonance imaging of the brain
Jan Klohs1, Way Cherng Chen2, Rikita Araki3
1Bruker BioSpin GmbH & Co. KG, Ettlingen, Germany. jan.klohs@bruker.com.
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Functional magnetic resonance imaging (fMRI), exploiting the blood oxygen level-dependent (BOLD) contrast, is the most widely used technique to study brain function. Combined with tools from biotechnology, molecular biology, and genetics, preclinical fMRI offers unparalleled opportunities to experimentally test causal hypotheses that are beyond the reach of human research. Here, we review recent progress in MRI hardware development, provide recommendations for BOLD fMRI protocol optimization, and discuss recent applications.
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