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Overview of Cell Death01:30

Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
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Necrosis01:16

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Iron and Cell Death.

Giorgia Federico1, Marialuisa Moccia2, Francesca Carlomagno3

  • 1Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università Federico II, Napoli, Italy.

Advances in Experimental Medicine and Biology
|July 2, 2025
PubMed
Summary

Iron is vital for cell functions but can trigger cell death like apoptosis and ferroptosis under certain conditions. This chapter explores iron

Keywords:
ApoptosisFerroptosisNFR2NecroptosisROS

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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
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Area of Science:

  • Cellular Biology
  • Biochemistry
  • Nutritional Science

Background:

  • Iron is an essential micronutrient crucial for numerous cellular processes.
  • Dysregulation of iron homeostasis can lead to detrimental effects on cells.
  • Iron overload or deficiency impacts cellular health and function.

Purpose of the Study:

  • To elucidate the dual role of iron in cellular pathways.
  • To investigate the mechanisms by which iron induces cell death.
  • To detail the signaling pathways implicated in iron-mediated cell death.

Main Methods:

  • Literature review of iron metabolism and cell death.
  • Analysis of signaling cascades involved in apoptosis, necroptosis, and ferroptosis.
  • Examination of iron's redox activity in cellular damage.

Main Results:

  • Iron is indispensable for DNA replication, metabolism, and oxygen transport.
  • Excess iron can promote programmed and unprogrammed cell death.
  • Specific signaling pathways are activated by iron to induce apoptosis, necroptosis, and ferroptosis.

Conclusions:

  • Iron's role in cellular function is complex, encompassing both essential support and potential toxicity.
  • Understanding iron-mediated cell death pathways is critical for therapeutic interventions.
  • Further research into iron's redox signaling is warranted.