Related Experiment Video
Updated: Sep 17, 2025
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Sarcopenic obesity, physical activity, and their combined impact on biological aging in US adults
Che Wang1,2, Rujie Zheng3, Wenjuan Song3
1School of Medicine, Nankai University, Tianjin, China.
Objective:
Our study aimed to examine the independent and combined associations of sarcopenia, sarcopenic obesity (SO) and physical activity (PA) status with phenotypic age acceleration (PhenoAgeAccel) in US adults.
Method:
The analyses included 9661 participants from the National Health and Nutrition Examination Survey (NHANES) 2005-2010 & 2015-2018. PhenoAgeAccel was calculated as the residuals from regressing phenotypic age (PhenoAge) on chronological age. Sarcopenia and SO were identified using the FNIH definition. Weighted multivariable logistic regression models, along with stratified and sensitivity analyses, were employed to evaluate the associations between sarcopenia, SO, and PhenoAgeAccel. Additionally, the population attributable fraction (PAF) was calculated to estimate the percentage of PhenoAgeAccel cases that could potentially be prevented by eliminating SO or PA deficiency.
Results:
A total of 9661 US adults were included in analysis. The weighted mean (SD) age was 32.78 (15.81) years, and 50.21% were males. Sarcopenia was not associated with PhenoAgeAccel in US adults in any subgroup or model. The multivariate-adjusted OR (95%CI) for PhenoAgeAccel with SO were 2.68 (2.13, 3.37) (p < 0.0001) for all, and 2.65 (2.10, 3.36) (p < 0.0001) for participants whose age ≤ 65 years old. Furthermore, compared to the combination of nonsarcopenia and adequate PA, combining SO and PA deficiency exhibited the highest risk of PhenoAgeAccel (OR 3.87; 95% CI 2.75, 5.46; p < 0.0001). SO increased the risk of PhenoAgeAccel by 29.3%, and adequate PA reduced the risk of PhenoAgeAccel by 9.1%, respectively. Notably, 18.5% increase was attributable to both SO and adequate PA concurrently.
Conclusion:
SO was significantly associated with higher risk of biological aging, especially in middle or young adults. Combining SO and PA deficiency enhanced the risk of accelerated aging. These findings underscore the importance of addressing SO through comprehensive lifestyle interventions to promote healthy aging and enhance health span.
More Related Videos
13:35Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Related Concept Videos
01:19The Effect of Aging on Tissues
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:26Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
01:24Obesity