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Related Concept Videos

Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

335
Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
335
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

471
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
471
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

639
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
639
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

413
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
413
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives01:22

Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives

307
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
307
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

152
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
152
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  11. Assessment Of The Effect Of Prokinetic Drugs On Transit Time And Gastrointestinal Cleanliness In Capsule Endoscopy.
  1. Home
  3. Research Domains
  5. Agricultural, Veterinary And Food Sciences
  7. Veterinary Sciences
  9. Veterinary Medicine (excl. Urology)
  11. Assessment Of The Effect Of Prokinetic Drugs On Transit Time And Gastrointestinal Cleanliness In Capsule Endoscopy.

Related Experiment Video

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Assessment of the effect of prokinetic drugs on transit time and gastrointestinal cleanliness in capsule endoscopy.

Andrzej Rychlik1, Ewa Kaczmar1, Ida Mikulska1,2

  • 1Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719, Olsztyn, Poland.

BMC Veterinary Research
|July 3, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Prokinetic drugs improve capsule endoscopy completeness in dogs but reduce image quality due to decreased gastrointestinal cleanliness. Further research is needed to balance transit time and image clarity for veterinary diagnostics.

Keywords:
CanineCapsule endoscopyDigestive tractDogs

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Area of Science:

  • Veterinary medicine
  • Gastroenterology
  • Diagnostic imaging

Background:

  • Flexible endoscopy is limited in scope, leaving parts of the canine small intestine unexamined.
  • Capsular endoscopy offers macroscopic assessment of the entire digestive tract.
  • Prokinetic drugs' effects on canine capsule endoscopy require evaluation.

Purpose of the Study:

  • To assess the impact of metoclopramide and cisapride on canine capsule endoscopy.
  • To evaluate the influence of these drugs on gastrointestinal transit time and image quality.

Main Methods:

  • Three-time endoscopic examinations were performed on each animal: baseline, post-metoclopramide, and post-cisapride.
  • The study compared capsule transit times and image quality across the three conditions.
Endoscopy
Prokinetic drugs

Main Results:

  • Metoclopramide prolonged capsule transit time (691.33 min), while cisapride shortened it (584.17 min).
  • The control group (no prokinetic drugs) yielded the highest quality images.

Conclusions:

  • Prokinetic drug administration enhances the likelihood of capturing the entire gastrointestinal tract in canine capsule endoscopy.
  • However, these drugs significantly compromise image quality due to reduced gastrointestinal cleanliness.