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Updated: Sep 17, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Home-based exercise for chemotherapy-induced peripheral neuropathy: a feasibility study.
Chieko Miyata1, Hirokazu Furuta2, Kohei Mizuno2
1Clinical Research Center, NHO Tokyo medical center, 2-5-1, Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan. kuma1mie2chibi3@yahoo.co.jp.
A hybrid exercise program combining outpatient and home-based sessions is feasible and safe for managing chemotherapy-induced peripheral neuropathy (CIPN). This approach improved physical function in patients undergoing cancer treatment.
Area of Science:
- Oncology
- Neurology
- Rehabilitation Medicine
Background:
- Chemotherapy-induced peripheral neuropathy (CIPN) significantly impacts quality of life.
- Optimal exercise protocols for CIPN management are not well-defined.
- Home-based rehabilitation shows promise for cancer patients.
Purpose of the Study:
- To assess the feasibility and safety of a 12-week hybrid rehabilitation intervention for CIPN.
- To evaluate a program combining supervised outpatient and home-based self-exercise.
- To support ongoing chemotherapy adherence through exercise.
Main Methods:
- Prospective observational study of 25 patients with CIPN.
- Intervention: supervised outpatient sessions plus home-based self-exercises.
- Outcomes: completion, adherence, nerve function, physical function, dexterity, QOL, chemotherapy adherence.
Main Results:
- 76% study completion rate; 88% adherence to both exercise components.
- Significant improvement in physical function (Cancer Functional Assessment Set).
- Sensory nerve function, dexterity, and QOL remained stable; chemotherapy adherence was favorable.
Conclusions:
- A combined outpatient-supervised and home-based exercise intervention is feasible and safe for CIPN.
- This hybrid model can be integrated into CIPN management protocols.
- Exercise may support patients undergoing chemotherapy.
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