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Updated: Sep 17, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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The role and therapeutic value of NUSAP1 in human cancers

Shenyuan Xu1,2, Ding Nan1,3, Ruiqi Liu4

  • 1Cancer Center, Department of Radiation Oncology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

Journal of Translational Medicine
|July 3, 2025
PubMed

Insights

Nucleolar and spindle-associated protein 1 (NUSAP1) is vital for cell division and is increasingly linked to cancer development. Understanding NUSAP1

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cancer incidence is rising globally, necessitating advancements in early diagnosis and treatment.
  • Nucleolar and spindle-associated protein 1 (NUSAP1) is a key regulator of mitosis, essential for accurate chromosome segregation.
  • NUSAP1's location and expression in proliferating cells suggest a role in oncogenesis.

Purpose of the Study:

  • To review the multifaceted roles of NUSAP1 in human cancers.
  • To elucidate the underlying mechanisms of NUSAP1's involvement in cancer progression.
  • To explore NUSAP1's potential as a diagnostic and prognostic biomarker.

Main Methods:

  • Literature review of studies on NUSAP1 and cancer.
  • Analysis of NUSAP1's function in cell division and its association with various cancer types.
  • Examination of research data on NUSAP1 expression patterns in tumors.

Main Results:

  • NUSAP1 is implicated in the pathogenesis of multiple cancers, including breast, cervical, lung, prostate, and liver cancers.
  • NUSAP1's function in microtubule-chromosome attachment is critical for maintaining genomic stability.
  • Aberrant NUSAP1 expression correlates with cancer development and progression.

Conclusions:

  • NUSAP1 plays a significant role in the development and progression of various human cancers.
  • NUSAP1's function as a mitotic regulator highlights its oncogenic potential.
  • NUSAP1 emerges as a promising biomarker for cancer detection and predicting patient outcomes.
Keywords:
BiomarkerCancerDiagnosisNUSAP1

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