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Siglecs: From Biomodulation to Immunotherapy.

Jia Chen1,2, Yumin Huang2, Yafei Wang2

  • 1College of Life Sciences, Northwest University, Xi'an, 710069, China.

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|July 3, 2025
PubMed
Summary
This summary is machine-generated.

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are key immune regulators in diseases. Targeting Siglecs shows promise for novel immunotherapies in cancer and autoimmune disorders.

Keywords:
Siglecsautoimmune diseasesimmune checkpointimmunomodulationimmunotherapysialic acid

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cancer Research

Background:

  • Siglecs (Sialic acid-binding immunoglobulin-like lectins) are immune cell receptors regulating inflammation and cancer immunity.
  • Current Siglec-targeted immunotherapies are limited despite their clinical trial progression.

Purpose of the Study:

  • To review Siglec roles in human diseases.
  • To explore novel therapeutic strategies targeting the Siglec-sialic acid axis.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, and Google Scholar (2015-2025).
  • Inclusion of studies on Siglec biology, immunomodulation, and therapeutic potential.
  • Exclusion of irrelevant studies and non-peer-reviewed materials.

Main Results:

  • Siglecs exhibit dual immune functions (activation/inhibition) and are implicated in cancer, autoimmune diseases, and viral infections.
  • Siglec15 and Siglec10 act as immune checkpoints in cancer.
  • Siglec2 and Siglec10 are involved in autoimmune diseases like SLE.

Conclusions:

  • Siglecs are crucial immunomodulators in cell-cell and pathogen interactions, vital in human diseases.
  • Targeting Siglecs presents promising therapeutic avenues for cancer and autoimmune diseases.
  • Further research is needed to fully exploit Siglec mechanisms and clinical applications.