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The Current and Potential Role of Pediatric Clinical Pharmacologists in Italy: A Review with Evidence Synthesis and

Anna Parzianello1, Marina Steyde1, Giuliana Decorti1

  • 1Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.

Current Medicinal Chemistry
|July 3, 2025
PubMed

Insights

Pediatric clinical pharmacologists are crucial for optimizing drug therapy in children due to their unique physiology. This study highlights their role in multidisciplinary teams, focusing on drug monitoring and safety in pediatric care.

Area of Science:

  • Pediatric Pharmacology
  • Clinical Pharmacy
  • Evidence-Based Medicine

Background:

  • Infants and young children possess unique physiological and developmental characteristics impacting drug pharmacokinetics and pharmacodynamics.
  • Pediatric drug therapy requires specialized knowledge distinct from adult or general patient care.
  • Multidisciplinary teams benefit from dedicated pediatric pharmacology specialists to enhance patient outcomes.

Purpose of the Study:

  • To delineate the role of pediatric clinical pharmacologists within the Italian pediatric clinical care framework.
  • To analyze the existing literature on pediatric pharmacology practices and contributions.
  • To provide insights into the current state of pediatric pharmacologist involvement in clinical settings.

Main Methods:

  • A systematic literature review adhering to PRISMA guidelines was performed.
  • PubMed database searches were conducted for articles published between January 2017 and March 2022.
  • The R package 'revtools' was utilized for title-based article screening and analysis.

Main Results:

  • A total of 1544 articles were initially identified, with 93 ultimately selected for analysis.
  • The selected literature predominantly focused on therapeutic drug monitoring and pharmacovigilance, including adverse drug reactions.
  • Key areas of pediatric clinical pharmacology practice were identified through the reviewed articles.

Conclusions:

  • The study offers an overview of multidisciplinary collaboration in preventing, diagnosing, and treating pediatric diseases.
  • Effective monitoring of pediatric treatments is facilitated by specialized pharmacological input.
  • The integration and long-term strengthening of pediatric clinical pharmacology within healthcare systems are recommended.
Abstract

Keywords:
Pediatric clinical pharmacologistclinical pharmacologymultidisciplinary teampediatricspharmacovigilance.therapeutic drug monitoring

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