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Antimicrobial Resistance Patterns in Pseudomonas Aeruginosa Isolated from Chronic Suppurative Otitis Media

Sadaf Razzak1,2,3, Muhammad Sohail4, Fakhur Uddin

  • 1Department of Pathology, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 3, 2025
PubMed
Abstract

Insights

Pseudomonas aeruginosa is a common cause of chronic suppurative otitis media (CSOM), often co-infecting with Staphylococcus aureus. High resistance to common antibiotics necessitates targeted stewardship for better CSOM outcomes.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Otolaryngology

Background:

  • Chronic suppurative otitis media (CSOM) is a persistent middle ear infection.
  • Pseudomonas aeruginosa is a significant opportunistic pathogen in various infections.
  • Understanding P. aeruginosa prevalence and resistance in CSOM is crucial for effective treatment.

Purpose of the Study:

  • To determine the frequency of P. aeruginosa in CSOM patients.
  • To assess the antimicrobial susceptibility patterns of P. aeruginosa isolates.
  • To identify potential risk factors associated with P. aeruginosa in CSOM.

Main Methods:

  • A cross-sectional study involving 302 CSOM patients in Karachi, Pakistan.
  • Ear discharge samples were cultured for pathogen identification.
  • Antimicrobial susceptibility testing of P. aeruginosa followed CLSI (2022) guidelines; chi-square test used for statistical analysis.

Main Results:

  • P. aeruginosa was identified in 46.7% of CSOM cases, often with Staphylococcus aureus.
  • High resistance rates were observed for piperacillin (46.1%), ceftazidime (35.5%), and cefepime (34.8%).
  • Carbapenem resistance was noted (imipenem 24.8%, meropenem 22%), while colistin showed no resistance.

Conclusions:

  • P. aeruginosa is a predominant pathogen in CSOM, frequently co-infecting with S. aureus.
  • Significant antimicrobial resistance to common antibiotics highlights treatment challenges.
  • Targeted antibiotic stewardship and interventions are vital for managing P. aeruginosa in CSOM.

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