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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Myasthenia Gravis: Overview and Treatment01:20

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Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
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Immunodeficiency Diseases01:25

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

Updated: Sep 17, 2025

Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies
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Anti-MOG Antibody Associated Disorders in Pakistan.

Tahira Mohammad1,2, Arsalan Ahmad, Tahir Aziz Ahmed1,2

  • 1Department of Immunology, Shifa International Hospital Limited, Islamabad, Pakistan.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|July 3, 2025
PubMed
Summary
This summary is machine-generated.

This study found that males were more frequently positive for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. MOG-associated disorders presented with visual impairment and muscle weakness in Pakistani patients.

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Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Myelin oligodendrocyte glycoprotein (MOG) is a key protein in the central nervous system.
  • Anti-MOG antibodies are associated with various demyelinating disorders.
  • Understanding MOG-associated disorders is crucial for autoimmune disease research.

Purpose of the Study:

  • To characterize clinicopathological features of anti-MOG antibody-positive patients in Pakistan.
  • To report treatment outcomes for MOG-associated disorders.
  • To analyze the demographic and clinical presentations in a Pakistani cohort.

Main Methods:

  • An observational study was conducted from January 2018 to December 2022.
  • Indirect immunofluorescence on EU 90 cells was used for anti-MOG antibody testing.
  • Clinical data were collected from medical records and patient interviews.

Main Results:

  • Out of 740 patients, 114 tested positive for anti-MOG antibodies; 59 were included in the final analysis.
  • The majority of seropositive patients were male (68.4%) with a mean age of 24 years.
  • Visual impairment (66%) and muscle weakness (61%) were the most common clinical presentations.

Conclusions:

  • A higher proportion of males tested positive for anti-MOG antibodies in this Pakistani population.
  • MOG-associated disorders affect both children and adults, with visual impairment and muscle weakness being frequent symptoms.
  • Isolated transverse myelitis was identified as a primary clinical phenotype.