Related Experiment Video
Updated: Jul 12, 2026

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
Published on: August 23, 2016
Association of Toll-like receptor 3 rs3775291 with Zika virus infection in Brazil
Christiane Maria Ayo1, Amarilis Giaretta de Moraes2,3, Laise Nayana Sala Elpídio2,3
1Faculty of Medicine of São José do Rio Preto, Department of Dermatological, Infectious and Parasitic Diseases, Laboratory of Immunogenetics, São José do Rio Preto 15090-000, SP, Brazil.
Background:
Zika virus (ZIKV) is an emergent pathogen known for the outbreak in early 2015, causing significant consequences, of which congenital ZIKV syndrome is the most severe manifestation. Toll-like receptors (TLRs) are important for the appropriate function of the innate immune response against pathogens. The presence of mutations in TLR genes can potentially result in altered susceptibility to diseases. Thus, this study aimed to investigate the influence of TLR2 rs5743708, TLR3 rs3775291, TLR4 rs4986790, TLR4 rs4986791, TLR6 rs5743810 and TLR7 rs179008 polymorphisms in ZIKV infection in a case-control study.
Methods:
The study enrolled 142 patients with ZIKV that sought medical care with ZIKV-related symptoms during the ZIKV outbreak and 142 controls. Genotyping was carried out by PCR-RFLP. Multivariate and χ2 analyses were performed to assess associations between polymorphisms and disease.
Results:
The dominant inheritance model revealed an increased risk for patients who were carriers of the TLR3 rs3775291 T allele. The C/T-T/T genotypes were significantly increased in patients rather than controls compared with the C/C genotype (OR=1.76, 95% CI 1.05 to 2.94; p=0.03).
Conclusions:
Our data support the literature and suggest that the variant rs3775291 in TLR3 may confer susceptibility to ZIKV infection in the Brazilian population.
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
American Trypanosomiasis

