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Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Maternal Sirolimus Treatment Reverses Cardiac Rhabdomyoma-Induced Hydrops Fetalis in a Twin Gestation With Tuberous

David M Ritter1,2, Kristin Schneider2,3, Nkiru Ezeakudo4

  • 1Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

American Journal of Medical Genetics. Part A
|July 3, 2025
PubMed

Keywords:
fetalmTOR inhibitorsirolimustuberous sclerosis

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Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...