Related Experiment Video
Updated: Sep 17, 2025

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
Published on: February 22, 2015
Malignant Transformation of Glioblastoma: One Step at a Time
John J Y Lee1,2, Mario L Suvà1,2
1Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
None:
In this issue of Cancer Discovery, Kim and colleagues characterize the transcriptional and epigenomic changes associated with gradual transformation of murine subventricular zone neural stem cells into glioblastoma, identifying an intermediary precancerous stage. Analysis of human glioblastoma and tumor-free subventricular zone tissues hints at the presence of precancerous cells with transcriptional similarity to murine precancerous cells and distinct aneuploidy from the bulk tumor. See related article by Kim et al., p. 1377.

