Emetic effect of triazolopyrimidine, a pyrimidine compound, in dogs

The intention of this study was to determine the minimum required dosage of triazolpyridine (TAP) to consistently induce emesis in canines. We administered single oral doses of TAP to 42 adult beagle dogs. The effect of TAP dosage on emesis was highly significant. The effective emetic dosages were 4.0 mg/10 ml water/animal (p less than 0.05) and 8.0 mg/10 ml water/animal (p less than 0.01). In all the dogs tested, 8.0 mg of TAP successfully induced emesis. The mean latency of emesis in the beagle group studied was 15 min, 54 sec (95% confidence limits = 8 min, 11 sec to 23 min, 38 sec). Intravenous apomorphine HCL was used to demonstrate the effectiveness of anti-emetic pretreatment with subcutaneous chlorpromazine (CPZ). Pretreatment with CPZ appeared to inhibit apomorphine-induced emesis, but did not modify the emetic response elicited by TAP. Emesis following the administration of TAP was considered a result of direct action of TAP upon the gastrointestinal mucosa. Eighty adult mongrel dogs were also given TAP doses of 8.0 mg/10 ml water/animal, with 100% effectiveness in inducing emesis.