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Improving pediatric heart failure outcomes through collaboration and innovation: The current status of the Advanced

Lydia K Wright1, David M Peng2, Joseph A Spinner3

  • 1Heart Center, Nationwide Children's Hospital, Columbus, OH.

JHLT Open
|July 3, 2025
PubMed

Insights

The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) improves pediatric heart failure care using real-world data. This learning health system enhances device access and care practices for better patient outcomes.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Heart Failure Management

Background:

  • The Advanced Cardiac Therapies Improving Outcomes Network (ACTION) was established in 2017.
  • It functions as a learning health care system.
  • Its primary goal is to improve outcomes for pediatric and congenital heart disease patients experiencing heart failure.

Purpose of the Study:

  • To summarize the network's evolution and key focus areas.
  • To highlight advancements in pediatric heart failure care.
  • To showcase the impact of real-world data utilization.

Main Methods:

  • Formation of a collaborative network of stakeholders.
  • Collection and analysis of real-world data.
  • Focus on key areas: ventricular assist devices (VAD), heart failure, muscular dystrophy, and Fontan procedures.

Main Results:

  • Expanded scope from VAD to comprehensive heart failure management.
  • Improved understanding of best practices in pediatric heart failure care.
  • Increased access to pediatric-labeled devices previously approved only for adults.

Conclusions:

  • ACTION has significantly contributed to advancing pediatric heart failure care.
  • Real-world data is crucial for improving treatment strategies and device accessibility.
  • The network's work spans critical areas, demonstrating a holistic approach to complex pediatric cardiac conditions.

Keywords:
Congenital heart diseaseHeart failureLearning health networkMuscular dystrophyVentricular assist device

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