[Posttraumatic regeneration of the skeletal muscles in certain forms of hypovitaminosis B1]

Light microscopy was employed to study the development of posttraumatic aseptic inflammation and subsequent regeneration in the affected musculus soleus in different patterns of hypovitaminosis B1. Alimentary deficiency of thiamine entailed pronounced retardation of the post-traumatic inflammation. The growth of macrophage density and formation of the pool of the regenerating cells were also retarded. On day 21 the regeneration pool showed an elevated content of the connective tissue. During long-term administration of oxythiamine in a dose of 10 mg/kg with a 12-hour interval, the development of the inflammatory response was marked by similar alterations, but the formation of muscle fibers and connective tissue proceeded more uniformly. A single administration of oxythiamine in a dose of 200 mg/kg did not bring about any substantial impairment of the early stages of regeneration. The alterations observed can be associated with different degree of inhibition of the activity of TDF-containing enzymes and derangement of the function of the nervous system.