Related Experiment Video
Updated: Jul 4, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
6.7K
Future directions in prognostic modeling for dengue-induced severe hepatitis
Chen Wang1, Hong Hu2, Yun Song2
1Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
World Journal of Hepatology
|July 3, 2025
Summary
The Model for End-Stage Liver Disease score reliably predicts mortality in dengue-induced severe hepatitis. The Easy Albumin-Bilirubin score also shows utility, though current models need refinement for clinical use.
Area of Science:
- Hepatology
- Infectious Diseases
- Critical Care Medicine
Background:
- Investigates prognostic scoring for acute liver failure and in-hospital mortality in dengue-induced severe hepatitis.
- Evaluates the predictive performance of established scoring systems.
Discussion:
- Compares the Model for End-Stage Liver Disease (MELD) score and the Easy Albumin-Bilirubin (EAB) score for prognostic accuracy.
- Highlights limitations of current prognostic models in real-world clinical settings.
Key Insights:
- The MELD score is validated as a highly reliable predictor of mortality.
- The EAB score demonstrates practical utility as a simpler prognostic tool.
- Current models require improvement for better clinical implementation.
Outlook:
- Proposes future research directions to enhance prognostic accuracy for liver dysfunction.
- Suggests broadening the scope of prognostic models to include other viral infections.
- Aims to improve clinical decision-making and patient outcomes in severe hepatitis.
Related Concept Videos
01:15Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...