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Updated: May 13, 2026

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
CT-based deep learning radiomics analysis for preoperative Lauren classification in gastric cancer and explore the
Ming Cheng1,2, Yimin Guo3,4, Huiping Zhao5
1Department of Medical Information, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Purpose:
This study aimed to investigate the usefulness of CT-based deep learning radiomics analysis (DLRA) for preoperatively differentiating Lauren classification in gastric cancer (GC) patients and explore the tumor microenvironment.
Methods:
578 patients were recruited from January 2015 to June 2024, and divided into the training cohort (n = 311), the internal validation cohort (n = 132), and the external validation cohort (n = 135). Clinical characteristics were collected. Radiomics features were extracted from CT images at arterial phase (AP) and venous phase (VP). A radiomics nomogram incorporating radiomics signature and clinical information was built for distinguishing Lauren classification, and its discrimination, calibration, and clinical usefulness were evaluated. RNA sequencing data from The Cancer Imaging Archive database were used to perform transcriptomics analysis.
Results:
The nomogram incorporating the two radiomics signatures and clinical characteristics exhibited good discrimination of Lauren classification on all cohorts [overall C-indexes 0.815 (95 % CI: 0.739-0.869) in the training cohort, 0.785 (95 % CI: 0.702-0.834) in the internal validation cohort, 0.756 (95 % CI: 0.685-0.816) in the external validation cohort]. It outperformed the clinical model in predictive ability. The calibration and decision curve substantiated the model's excellent fitness and clinical applicability. Further, transcriptomics analysis showed that the differentially expressed genes of different Lauren types were mainly enriched in pathways related to cell contraction and migration, and the infiltration degree of various immune cells was also significantly different.
Conclusions:
DLRA effectively differentiated Lauren classification in GC, and our analysis of transcriptomic data across different Lauren subtypes revealed the heterogeneity within the GC microenvironment.
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