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PABPN1 as a pan-cancer biomarker: prognostic significance and association with tumor immune microenvironment

  • 0The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Frontiers in Immunology +

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July 3, 2025

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July 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Poly(A) binding protein nuclear 1 (PABPN1) shows elevated expression in cancers and correlates with tumor mutational burden and immune cell infiltration. PABPN1 is a promising pan-cancer biomarker for prognosis and immunotherapy.

Area Of Science

  • Oncology
  • Molecular Biology
  • Immunology

Background

  • Poly(A) binding protein nuclear 1 (PABPN1) is implicated in mRNA processing and nuclear export.
  • Its role as a pan-cancer biomarker for prognosis and immunotherapy remains to be fully elucidated.

Purpose Of The Study

  • To investigate the potential of PABPN1 as a pan-cancer biomarker.
  • To analyze the association of PABPN1 expression with tumor characteristics and immune infiltration.

Main Methods

  • Utilized TCGA and GEO datasets for PABPN1 expression analysis.
  • Assessed prognostic implications using GEPIA, Kaplan-Meier plotter, and PrognoScan.
  • Correlated PABPN1 with tumor mutational burden (TMB), microsatellite instability (MSI), neoantigens, and tumor-infiltrated lymphocytes (TILs) via SangerBox and UALCAN.
  • Validated findings through cell line experiments.

Main Results

  • PABPN1 expression was higher in human cancers than in normal tissues.
  • PABPN1 expression strongly correlated with TMB, MSI, and neoantigens.
  • Significant associations were found between PABPN1 and TILs, particularly in urogenital cancers.
  • PABPN1 coexpression networks were involved in immune response and antigen presentation.
  • Downregulation of PABPN1 reduced MRPS15 and GPx mRNA levels in cancer cells.

Conclusions

  • PABPN1 serves as a potential prognostic and immunological pan-cancer biomarker.
  • Its expression is linked to key cancer hallmarks and immune interactions.

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