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ER stress genes (COL1A1, LOXL2, VWF) predicts IKK-16 as a Candidate therapeutic target for colitis-related inflammation and fibrosis suppression

  • 0Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Frontiers in Immunology +

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July 3, 2025

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July 3, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Endoplasmic reticulum stress (ERS) is linked to ulcerative colitis (UC) fibrosis. Key genes like COL1A1, LOXL2, and VWF drive UC fibrosis, with IKK-16 showing therapeutic potential.

Area Of Science

  • Gastroenterology
  • Immunology
  • Molecular Biology

Background

  • Endoplasmic reticulum stress (ERS) role in ulcerative colitis (UC) immune-inflammatory dysregulation and intestinal fibrosis is not fully understood.
  • Identifying ERS-related genes is crucial for understanding UC pathogenesis and developing targeted therapies.

Purpose Of The Study

  • To identify ERS-related genes implicated in UC fibrosis.
  • To explore potential therapeutic targets for UC-associated intestinal fibrosis.

Main Methods

  • Analysis of public datasets to identify differentially expressed ERS-related genes (DE-ERGs).
  • Machine learning identified VWF, MZB1, COL1A1, and LOXL2 as key regulators.
  • Immune infiltration, protein-protein interaction (PPI) network, and gene set variation analyses (GSVA) were employed.
  • Drug prediction utilized the Connectivity Map (CMap) database and literature review.

Main Results

  • COL1A1, LOXL2, and VWF were identified as key drivers of UC intestinal fibrosis.
  • Immune infiltration and PPI network analyses supported the roles of these genes.
  • IKK-16 demonstrated the highest binding affinity among predicted drugs for treating UC fibrosis.

Conclusions

  • ERS-related genes, specifically COL1A1, LOXL2, and VWF, likely regulate UC fibrosis via immune cell interactions.
  • IKK-16 emerges as a promising therapeutic candidate for UC fibrosis.
  • The study offers novel insights into UC pathogenesis and potential clinical strategies.

Keywords:

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