Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Diabetic Ketoacidosis l: Introduction

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Triplet therapy with darolutamide and docetaxel for metastatic castration-sensitive prostate cancer: a multicenter real-world study.

Japanese journal of clinical oncology·2026

Same author

Real-World Outcomes After Radical Cystectomy for Muscle-Invasive Bladder Cancer in Japan: A Nationwide Descriptive Study From the National Clinical Database.

International journal of urology : official journal of the Japanese Urological Association·2026

Same author

Age-stratified outcomes of radical cystectomy for muscle-invasive bladder cancer: a nationwide multicenter study of 1867 patients in Japan.

Japanese journal of clinical oncology·2026

Same author

Spatial Multiomic Analyses Reveal Carcinogenic Pathways in End-Stage Renal Disease.

Cancer discovery·2025

Same author

A Case of Metastatic Castration-Resistant Prostate Cancer With <i>RAD54L</i> Mutation Responding to Niraparib.

IJU case reports·2025

Same author

Impact and Risk Factors of Diagnostic Delay in Patients With Testicular Cancer: A Multicenter Retrospective Study.

International journal of urology : official journal of the Japanese Urological Association·2025

Search research articles

Related Experiment Video

Updated: May 5, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Metformin-Associated Lactic Acidosis During Docetaxel Therapy for Castration-Resistant Prostate Cancer: A Case

Y Inoue^1,2, A Niimi^1,3, T Kudo⁴

¹Department of Urology The New Tokyo Hospital Chiba Japan.

IJU Case Reports

|July 3, 2025

Summary

Elderly cancer patients on metformin and docetaxel chemotherapy are at high risk for lactic acidosis. Careful sick-day management and monitoring are crucial to prevent fatal outcomes like the one described.

Keywords:

castration‐resistant prostate cancer chemotherapy metformin‐associated lactic acidosis patient education sick‐day management

More Related Videos

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Related Experiment Videos

Last Updated: May 5, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Area of Science:

Oncology
Endocrinology
Pharmacology

Background:

Docetaxel and prednisolone are standard treatments for castration-resistant prostate cancer.
Prednisolone increases diabetes risk, while docetaxel can cause febrile neutropenia.
Metformin is used for diabetes but carries a risk of lactic acidosis, especially in elderly cancer patients.

Purpose of the Study:

To report a fatal case of metformin-associated lactic acidosis in an elderly patient undergoing docetaxel chemotherapy.
To highlight the risks of metformin use in elderly cancer patients with diabetes during chemotherapy.

Main Methods:

Case report of a 70-year-old male with castration-resistant prostate cancer and diabetes.
Retrospective review of medication use and clinical course.
Analysis of potential contributing factors to metabolic acidosis and shock.

Main Results:

The patient developed febrile neutropenia and progressed to shock with severe metabolic acidosis.
Continued metformin use during prodromal symptoms of illness was noted.
Death occurred despite intensive care, including continuous renal replacement therapy.

Conclusions:

Metformin likely exacerbated lactic acidosis in this patient, potentially worsening septic shock.
Emphasizes the critical need for comprehensive sick-day education and vigilant monitoring for elderly cancer patients on metformin during chemotherapy.