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Updated: Sep 17, 2025
In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Clear Cell Papillary Renal Cell Carcinoma Incidentally Discovered in a Patient With Normal Renal Function: A Case
Toru Inoue1, Masahiro Fuse1, Satoki Abe1
1Department of Urology Faculty of Medicine, Oita University Yufu Oita Japan.
Introduction:
Clear cell papillary renal cell carcinoma is a distinct histopathological entity first characterized in patients with end-stage renal disease. Although increasingly reported in patients with normal renal function, it remains relatively unfamiliar in routine clinical practice.
Case Presentation:
A 75-year-old male with normal renal function presented with an incidentally discovered left renal mass. Radiological evaluation revealed a mass with a distinct enhancement pattern. Considering the patient's preference for surgical management, robot-assisted partial nephrectomy was performed, confirming clear cell papillary renal cell carcinoma, with immunohistochemistry demonstrating diffuse cytokeratin 7-positivity, alpha-methylacyl-CoA racemase-negativity, and cup-shaped carbonic anhydrase IX staining.
Conclusion:
This case demonstrated the characteristic features of clear cell papillary renal cell carcinoma in a patient with normal renal function. Nephron-sparing surgery and rigorous follow-up protocols are crucial management strategies. Future studies with larger cohorts are needed to define the natural history and optimal management of clear cell papillary renal cell carcinoma.
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