Related Experiment Video

Updated: Sep 17, 2025

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

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[Chronic Kidney Disease and SGLT2 Inhibitors: Single Center Experience]

Federica Spaltini1, Elvira Mancini1, Patrizia Vio1

  • 1SOC Nefrologia e dialisi, Ospedale Castelli, Verbania.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|July 3, 2025
PubMed

Insights

This study explored the effectiveness and safety of Dapagliflozin for patients with chronic kidney disease. Results indicate its potential as a new treatment option for slowing kidney disease progression.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Chronic kidney disease (CKD) is prevalent, often underdiagnosed, and a significant risk factor for cardiovascular events and mortality.
  • Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) have been primary treatments for CKD.
  • Sodium-glucose cotransporter 2 (SGLT2) inhibitors represent a newer therapeutic class for kidney disease.

Purpose of the Study:

  • To evaluate the efficacy and safety of Dapagliflozin in a nephropathic patient population.
  • To assess Dapagliflozin's role in managing chronic kidney disease progression.

Main Methods:

  • A single-center observational study conducted from February 2023 to June 2024.
  • Enrolled 21 diabetic and 7 non-diabetic patients with CKD on maximal renin-angiotensin system blockade.
  • Monthly blood tests and urine cultures (as needed) were collected.

Main Results:

  • The study assessed the efficacy and safety of Dapagliflozin in patients with chronic kidney disease.
  • Data on patient outcomes and potential side effects were collected.

Conclusions:

  • Dapagliflozin shows promise as a therapeutic option for patients with chronic kidney disease.
  • Further research may confirm its role in slowing disease progression and improving cardiovascular outcomes.
Keywords:
Chronic kidney diseaseSGLT2 inhibitorsslow progression

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