[Circadian behavior of hemostaseologic parameters in diabetic patients and metabolically healthy individuals]

In three groups of test persons [10 persons each with healthy metabolism under fasting (A) and intake of food (B); 10 insulin-dependent diabetics (C)] the determinations of the thromboplastin time, the partial thromboplastin time, the bleeding time, the spontaneous fibrinolytic activity, the number of thrombocytes and the aggregation of platelets were carried out on the day (A) and round the clock (B abd C), respectively. The values of the fasting persons with healthy metabolism distributed themselves on the day constantly in the area of width of errors. Under food intake persons with healthy metabolism showed circadian variations of the several tests. In diabetics the parameters of haemostasis revealed in the course of day a clear increase of the unstable behaviour compared with the control group B. There were no relations to the actual blood sugar value. In a tendency to more coagulation-active values in the late afternoon interindividually a general biorhythmical behaviour pattern could not be recognized. The proved increased circadian labilisation of the haemostasis potential in diabetics deserves more attention with regard to the connection between thrombophilia and atherogenesis.