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Related Concept Videos

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

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Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle01:19

Inductively Coupled Plasma Atomic Emission Spectroscopy: Principle

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Inductively coupled plasma (ICP) is the most widely used plasma source in atomic emission spectroscopy (AES), also known as Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The ICP source, or torch, consists of three concentric quartz tubes with argon gas flowing through them. A spark from a Tesla coil initiates the ionization of argon, generating a high-temperature plasma.
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Mass Analyzers: Overview01:13

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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
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Image Fusion for Improving the Spatial Resolution of LA-ICP-MS Imaging.

Teerapong Jantarat1, Jeerapat Doungchawee1, Xianzhi Zhang1

  • 1Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01002, United States.

Analytical Chemistry
|July 3, 2025
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Summary
This summary is machine-generated.

This study introduces a new method to improve laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging resolution. By fusing LA-ICP-MS with optical microscopy, researchers can achieve detailed elemental mapping of nanomaterials in organs.

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Area of Science:

  • Analytical Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) imaging is crucial for analyzing elemental distributions in biological tissues.
  • Current LA-ICP-MS imaging faces challenges in balancing spatial resolution, sensitivity, and acquisition time, limiting nanomaterial characterization in organs.

Purpose of the Study:

  • To enhance the spatial resolution of LA-ICP-MS imaging for detailed nanomaterial distribution analysis in biological tissues.
  • To overcome the trade-offs between resolution, sensitivity, and acquisition time in current LA-ICP-MS techniques.

Main Methods:

  • Developed an image fusion approach computationally integrating LA-ICP-MS and optical microscopy data.
  • Applied the fusion technique to achieve 5 μm resolution LA-ICP-MS images without altering hardware or operational parameters.

Main Results:

  • Achieved 5 μm spatial resolution in LA-ICP-MS images, significantly improving detail without compromising sensitivity or speed.
  • Enabled precise mapping of biological metals and nanomaterials within organ structures like the kidney, liver, and spleen.
  • Provided new insights into nanomaterial excretion pathways in the liver and immune responses to gold nanoparticles in the spleen.

Conclusions:

  • The image fusion method enhances LA-ICP-MS spatial resolution, offering detailed suborgan elemental mapping.
  • This approach is a valuable tool for advancing the study and development of nanomaterial-based drug delivery systems.
  • The enhanced resolution provides critical data for understanding nanomaterial behavior in vivo.