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Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
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Relationships Among Glaucoma, Cardiovascular Diseases, and Mortality

Luciano Quaranta1, Alessia A Galbussera2, Mauro Tettamanti3

  • 1Centro Oculistico Italiano, Brescia, Italy.

Advances in Therapy
|July 3, 2025
PubMed

Insights

Glaucoma patients aged 50+ have a higher mortality risk and increased incidence of stroke. Managing comorbidities like diabetes and hypertension is crucial for improving health outcomes in glaucoma individuals.

Area of Science:

  • Ophthalmology
  • Public Health
  • Epidemiology

Background:

  • Glaucoma is a leading cause of irreversible blindness globally.
  • Understanding comorbidity and mortality risks in glaucoma patients is essential for public health.
  • Previous studies have not fully elucidated the mortality and comorbidity profiles of incident glaucoma cases.

Purpose of the Study:

  • To investigate comorbidity rates and mortality risk in patients with newly diagnosed glaucoma.
  • To compare cardiovascular disease incidence between glaucoma patients and controls.
  • To identify factors influencing outcomes in glaucoma patients.

Main Methods:

  • Retrospective analysis of administrative data from the Lombardy Region (Italy) from 2017-2020.
  • Inclusion of 14,138 incident glaucoma cases and 42,414 controls aged 50 and above.
  • Ascertainment of glaucoma using drug prescriptions, hospitalizations, interventions, and healthcare co-payment exemptions.

Main Results:

  • Glaucoma patients (11.6%) had a higher mortality rate than controls (10.5%), with a hazard ratio of 1.07.
  • Increased incidence of stroke was observed in glaucoma patients (HR 1.10).
  • Glaucoma patients exhibited higher comorbidity rates, notably for diabetes mellitus (16.7% vs. 11.0%) and hypertension (62.2% vs. 58.1%).

Conclusions:

  • Glaucoma is associated with an elevated risk of mortality and stroke.
  • Age significantly influences mortality and peripheral arterial disease outcomes in glaucoma patients.
  • Effective management of comorbidities is vital for improving the health and quality of life of individuals with glaucoma.
Abstract

Keywords:
General mortalityGlaucomaHeart attackPeripheral artery diseaseStroke

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