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Updated: Sep 17, 2025

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Using Quality Function Deployment to Design an Image-Guided, Multibiopsy Tool for Neurosurgical Applications.

Kaytlin Andrews1, Hunter Dejean2, Cameron MacLeod2

  • 1Department of Medicine, Queen's University, Kingston , Ontario , Canada.

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|July 3, 2025
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Summary
This summary is machine-generated.

A novel optically tracked biopsy device precisely collects spatially defined brain tumor samples, improving molecular characterization for personalized medicine. This tool offers consistent, efficient, and easy-to-use brain biopsy collection.

Keywords:
3D printingBiopsyBrain tumorQuality Function Deployment

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Area of Science:

  • Neurosurgery
  • Biotechnology
  • Oncology

Background:

  • Molecular characterization of heterogeneous tumors like primary brain tumors requires precise tissue sampling.
  • Existing neurosurgical tools are inadequate for modern molecular characterization, limiting analysis to single regions.
  • A novel biopsy device is needed for spatially defined, cross-contamination-free tissue collection.

Purpose of the Study:

  • To introduce and validate a novel, optically tracked biopsy device for precise, reproducible, and spatially registered tissue collection.
  • To improve the molecular characterization of heterogeneous tumors.
  • To advance personalized tumor characterization and treatment strategies.

Main Methods:

  • Development of prototypes using Quality Function Deployment for user and technical requirements.
  • Iterative modeling, 3D printing, proof-of-concept, and phantom testing.
  • Comparative testing against Yasargil forceps with neurosurgeons and students; clinical feasibility assessment with intraoperative samples.

Main Results:

  • The lead design is an optically tracked capsule attached to Frazier suction, securely containing samples.
  • The capsule method reduced variability in sample weight and collection time compared to forceps.
  • The device demonstrated ease of use, with students achieving comparable results to experienced surgeons; clinical testing showed no differences in sample variability or tissue preservation.

Conclusions:

  • The optically tracked navigated biopsy tool provides a low-cost, efficient, and consistent method for brain biopsy.
  • The device is suitable for precision medicine and translational research.
  • This novel tool enhances the ability to molecularly characterize spatially heterogeneous tumors.