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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

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Fatal cryptococcal meningitis in an immunocompetent patient.

Minoosh Shabani¹, Bahareh Bashardoust², Aleksandra Barac³

¹Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Infection in Developing Countries

|July 3, 2025

Summary

This case report details cryptococcal meningitis (CM) in an immunocompetent male caused by Cryptococcus gattii. It highlights diagnostic challenges and the significant morbidity of cryptococcosis, even in healthy individuals.

Keywords:

Cryptococcal meningitis Cryptococcus gatii immunocompetence

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Area of Science:

Infectious Diseases
Mycology
Neurology

Background:

Cryptococcal meningitis (CM) is an opportunistic infection primarily affecting immunocompromised individuals.
It is commonly caused by the fungus Cryptococcus neoformans.
This case involves an unusual presentation in an immunocompetent host.

Purpose of the Study:

To report a rare case of CM in an immunocompetent individual.
To highlight the diagnostic and management complexities of cryptococcosis.
To emphasize the need for vigilance in understanding cryptococcal infection epidemiology.

Main Methods:

Case presentation of an immunocompetent male with CM.
Identification of the causative agent as Cryptococcus gattii molecular type VGI.

Main Results:

The case presented diagnostic and management challenges.
Cryptococcosis was associated with significant patient morbidity.
The findings underscore the importance of considering CM in diverse patient populations.

Conclusions:

Cryptococcal meningitis can occur in immunocompetent individuals.
Cryptococcus gattii VGI is a potential pathogen in this population.
Vigilance in diagnosis and management is crucial for cryptococcosis.