Related Experiment Video
Updated: Sep 17, 2025
Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
Insights into correlations between H. pylori infection and chronic hepatitis C disease progression: A Comparative
Ahmed Ragab1, Asmaa M Elbrolosy2, Naglaa S Elabd1
1Tropical Medicine Department, Faculty of Medicine - Menoufia University, Menoufia, Egypt.
Background:
Accumulating evidence implicated H. pylori infection in the disease progression of patients with chronic liver. Highly virulent H. pylori mediate proinflammatory cytokines and ensuing inflammatory alterations. We aimed to assess the correlation between H. pylori infection and disease progression in chronic hepatitis C (HCV) patients with special concern on virulence traits and susceptibility patterns of isolated H. pylori strains.
Methods:
After clinical, laboratory, and radiological evaluations, 189 chronic HCV patients were assigned into Group I (74 patients with chronic HCV), Group II (77 cirrhotic patients), and Group III (38 hepatocellular carcinoma (HCC) patients on top of cirrhosis). Fecal samples were analyzed using ELISA to detect H. pylori antigens. Upper gastrointestinal (GIT) gastric biopsies were processed to identify and isolate H. pylori strains. PCR assay verified cagA, VacAs1 & VacAs2 gens in isolated strains to be correlated with the degree of hepatic disease.
Results:
H. pylori Ag in stool was identified in 73.02% of studied patients. H. pylori Ag was 55.4%, 84.4%, and 84.2% (p < 0.001); additionally, culture yielded viable H. pylori bacilli in 31.1%, 44.2%, and 55.3% (p = 0.039), and PCR assay revealed 47.8%, 85.3%, and 85.7% (p = 0.004) were positive for cagA and/or vacAs2 virulence genes in chronic hepatitis, cirrhosis, and HCC patients, respectively. The presence of H. pylori positive culture and/or genetic profile is associated with advanced-stage liver disease, hepatic encephalopathy, and portal hypertensive gastropathy.
Conclusions:
H. pylori infection should be assessed in all patients with liver impairment. Early H. pylori detection and subsequent eradication may lessen the severity of decompensation.
More Related Videos
05:23Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
09:05High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
Published on: November 21, 2014
Related Concept Videos
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...