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Updated: Sep 17, 2025
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Antibiotic stewardship program (ASP) implementation is more effective than the national action plan for rational drug
Cem Karaali1, Huseyin Esin1, Orhan Ureyen2
1Department of General Surgery, University of Health Sciences Izmir Faculty of Medicine, Tepecik Education and Research Hospital, Yenisehir, Izmir, Turkey.
Journal of Infection in Developing Countries
|July 3, 2025
Summary
A modified antibiotic stewardship program (mASP) and the National Action Plan for Rational Drug Use (NAPRDU) improved surgical prophylaxis (SP). The mASP demonstrated faster and more effective improvements in SP practices and discharge prescriptions.
Area of Science:
- Infectious Diseases
- Surgical Care
- Health Services Research
Background:
- Antibiotic stewardship programs (ASPs) are crucial for optimizing antibiotic use in healthcare settings.
- Surgical prophylaxis (SP) is a key area where ASPs can impact antibiotic resistance and patient outcomes.
- Evaluating the long-term effectiveness of different ASP models is essential for evidence-based practice.
Purpose of the Study:
- To compare the long-term effects of a modified antibiotic stewardship program (mASP) versus the National Action Plan for Rational Drug Use (NAPRDU) on surgical prophylaxis (SP) practices.
- To assess the impact of these programs on the continuation of SP in discharge prescriptions in general surgery clinics.
- To identify which program leads to more rapid and effective improvements in SP.
Main Methods:
- Retrospective examination of SP practices in two general surgery clinics (Clinic A: mASP, Clinic B: NAPRDU).
- Cross-sectional comparison using quarterly data from 2013, 2016, 2018, and 2023.
- Analysis of SP indication, duration, antibiotic use in prescriptions, and administration timing.
Main Results:
- Both mASP and NAPRDU led to significant long-term improvements in SP indication, duration (>24 hours), and antibiotic use in prescriptions.
- Improvements were observed across all stages of SP, except for administration timing (p < 0.05).
- Clinic A, utilizing mASP, showed significantly greater and faster improvements in these SP parameters compared to Clinic B (NAPRDU).
Conclusions:
- Both mASP and NAPRDU positively influence long-term SP practices and discharge prescription patterns in general surgery.
- The mASP demonstrated superior effectiveness and speed in improving SP practices, particularly concerning antibiotics in discharge prescriptions.
- These findings highlight the potential benefits of tailored ASP interventions for optimizing surgical prophylaxis.
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