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Association of monocyte and lymphocyte ratio with risk of abdominal aortic calcification
1Department of Cardiology, The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University, Huai'an, China.
Objectives:
The aim of the study was to evaluate the relationship between monocyte and lymphocyte ratio (MLR) with severe AAC.
Methods:
This cross-sectional study enrolled 3041 patients with AAC from the National Health and Nutrition Examination Survey 2013-2014. Abdominal aortic calcification detected with dual-energy X-ray absorptiometry was quantified using the Kauppila score system. We measured white blood cell, neutrophil, lymphocyte counts, monocyte counts, red blood cell, calcium, 25-VitD3, and phosphorus levels in blood samples. Multivariate logistic regression was performed to examine the association between MLR (as a qualitative or quantitative variable) and severe AAC morbidity.
Results:
Severe AAC was detected in 273 (9.0%) participants. Multivariate logistic regression analysis indicated that high MLR was an independent predictor of severe AAC (odds ratio [OR] 2.80, 95% confidence interval [CI] 1.04-7.50; P = 0.041).
Conclusions:
Elevated MLR levels are independently associated with higher odds for severe AAC, which can serve as a new risk factor in clinical practice.
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