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Exercise Training in Heart Failure: Clinical Benefits and Mechanisms
Louisa A Mounsey1,2, Meihan Guo1, Emily S Lau3
1CardioVascular Institute and Division of Cardiology, Department of Medicine (L.A.M., M.G., J.E.H.), Beth Israel Deaconess Medical Center, Boston, MA.
Circulation Research
|July 3, 2025
Summary
Exercise training offers significant benefits for heart failure (HF) patients, improving mortality, exercise capacity, and quality of life. This review explores the mechanisms behind these improvements and suggests future research directions for HF management.
Area of Science:
- Cardiology
- Exercise Physiology
- Molecular Medicine
Background:
- Clinical guidelines recommend exercise training for heart failure (HF).
- Exercise training's benefits and underlying mechanisms in HF require comprehensive review.
- Understanding these mechanisms can optimize HF management strategies.
Purpose of the Study:
- To review the clinical benefits of exercise training in heart failure (HF) patients.
- To explore the physiological and molecular mechanisms of exercise training in HF.
- To identify future research directions for exercise prescriptions in HF.
Main Methods:
- Systematic review of clinical trials focusing on HF.
- Analysis of key outcomes: mortality, hospitalization, exercise capacity, quality of life.
- Exploration of organ-specific and global physiological/molecular mechanisms.
Main Results:
- Exercise training improves key clinical outcomes in HF patients.
- Mechanisms involve enhanced oxygen transport, anti-inflammatory, immunomodulatory, and antioxidative effects.
- Neurohormonal regulation and interorgan crosstalk are also implicated.
Conclusions:
- Exercise training is a valuable intervention for HF management across various subtypes.
- Further research is needed to refine evidence-based exercise prescriptions for HF.
- Understanding molecular and physiological adaptations can guide personalized HF treatment.
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