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Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management
Vinayak Subramanian1, Wesley J Tucker2, Anthony E Peters3
1Division of Cardiology (V.S., A.P.), Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
Circulation Research
|July 3, 2025
Summary
Physical activity and exercise training can significantly mitigate the harmful biological effects of accelerated aging, improving health outcomes in aging populations. These interventions offer potent therapeutic benefits for age-related diseases.
Area of Science:
- Gerontology and Cardiovascular Medicine
- Exercise Physiology and Aging Research
Background:
- Global demographic shifts indicate a growing aging population, leading to an increased prevalence of age-related diseases.
- Biological aging is a complex, heterogeneous process influenced by genetics, environment, and behavior, manifesting across all organ systems.
- Accelerated aging phenotypes are linked to significant morbidity and mortality, with conditions like heart failure with preserved ejection fraction potentially stemming from this process.
Purpose of the Study:
- To review age-related changes in cardiovascular and peripheral tissues.
- To explore the implications of accelerated biological aging.
- To examine the effectiveness and mechanisms of physical activity and exercise in counteracting aging's detrimental effects.
Main Methods:
- This review synthesizes current literature on aging, cardiovascular health, and exercise.
- It analyzes age-related tissue changes and the concept of accelerated aging.
- The review discusses the therapeutic role and underlying mechanisms of physical activity and exercise.
Main Results:
- Physical activity and exercise training demonstrably modify the biological effects of accelerated aging.
- These interventions are associated with numerous health benefits and serve as effective treatments for age-related conditions.
- Exercise can curb deleterious aging effects and improve clinical outcomes in affected individuals.
Conclusions:
- Physical activity and exercise are crucial for managing accelerated aging and its associated diseases.
- Understanding the mechanisms by which exercise impacts aging tissues is key to optimizing therapeutic strategies.
- Regular exercise offers a powerful, non-pharmacological approach to enhance healthspan and combat age-related decline.
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