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Updated: Sep 17, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Euphothymifols a and B, novel bioactive bicyclic jatrophane-type diterpenoids from euphorbia thymifolia L
Jiang-Ying Cao1, Guang-Ying Lu2, Dong-Sheng Zhao1
1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Abstract:
Two new 5/12 bicyclic jatrophane-type diterpenoids, euphothymifols A and B (1-2), were obtained from Euphorbia thymifolia L. Their structures were defined by their spectroscopic data and GIAO NMR calculations as well as their biosynthetic pathway. Euphothymifols A (1) and B (2) exhibited inhibitory activities against nitric oxide (NO) production with IC50 values of 43.5 ± 1.54 μM (1) and 56.2 ± 1.67 μM (2) in LPS-induced BV-2 microglia cells.
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