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Related Concept Videos

  • Engineering
  • Manufacturing Engineering
  • Precision Engineering
  • 3d Printing Personalized Medications In A Hospital: Rapid And Non-destructive Dose Verification Of Printed Medicines Enabled By Miniaturised Spectroscopy.
  • Engineering
  • Manufacturing Engineering
  • Precision Engineering
  • 3d Printing Personalized Medications In A Hospital: Rapid And Non-destructive Dose Verification Of Printed Medicines Enabled By Miniaturised Spectroscopy.

    • Related Experiment Video

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    3D printing personalized medications in a hospital: Rapid and non-destructive dose verification of printed medicines enabled by miniaturised spectroscopy.

    Anna Kirstine Jørgensen1, Antoine Dowek2, Lucas Denis2

    • 1Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.

    Journal of Pharmaceutical Sciences
    |July 3, 2025

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Miniaturized near-infrared (NIR) and Raman spectrometers provide accurate, non-destructive quality control for three-dimensional printed (3DP) tamoxifen medications. This hub-and-spoke approach accelerates decentralized pharmaceutical manufacturing for clinical trials.

    Keywords:
    Additive manufacturing of drug productsChemometrics for drug quantificationExtrusion-based 3D printingPersonalised pharmaceuticalsPoint of care compoundingProcess analytical technology

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    Area of Science:

    • Pharmaceutical Technology
    • Analytical Chemistry
    • Medical Device Technology

    Background:

    • Three-dimensional printing (3DP) offers personalized medicine and decentralized pharmaceutical manufacturing.
    • Non-destructive quality control (QC) methods are essential for small-batch 3DP medicine production.
    • Current QC methods may not be suitable for rapid, point-of-care analysis in hospital pharmacies.

    Purpose of the Study:

    • To investigate miniaturized near-infrared (NIR) and Raman spectrometers as QC tools for 3DP tamoxifen medications.
    • To assess the accuracy and predictive capability of these spectroscopic methods for quantifying tamoxifen.
    • To evaluate the feasibility of a 'hub-and-spoke' model for developing QC methods in a hospital pharmacy setting.

    Main Methods:

    • Manufactured calibration samples with 30% w/w tamoxifen citrate in a research environment (hub).
    • Acquired spectral data using handheld NIR and Raman spectrometers in a hospital pharmacy (spoke).
    • Utilized a 'hub-and-spoke' approach for calibration and validation of 3DP tamoxifen capsules, analyzing both open and closed capsules.

    Main Results:

    • Both NIR and Raman spectrometers generated highly accurate and predictive models for tamoxifen quantification.
    • Spectra acquisition was successful through both open and closed capsule shells.
    • The developed models demonstrated suitability for rapid, non-destructive QC of 3DP tamoxifen medicines.

    Conclusions:

    • Miniaturized NIR and Raman spectrometers are effective non-destructive QC methods for 3DP pharmaceutical production in hospital pharmacies.
    • The 'hub-and-spoke' model accelerates the development of non-destructive chemometric models for decentralized 3DP medication manufacturing.
    • Future implementation depends on factors like system integration, cost, and safety.