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The omics techniques used in perineuronal nets research.

Sihan Huang1, Jiao Tang1, Xiao Wu1

  • 1College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan, China.

Experimental Neurology
|July 3, 2025
PubMed
Summary

This review explores how omics technologies reveal changes in perineuronal nets (PNNs) during neurodegenerative diseases (NDs). Understanding PNN alterations is key for diagnosing and treating these CNS disorders.

Keywords:
BiomarkersNeurodegenerative diseasesOmics techniquesPerineuronal nets

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Genomics

Background:

  • Neurodegenerative diseases (NDs) involve progressive central nervous system (CNS) neuronal degeneration.
  • Alterations in perineuronal nets (PNNs) are linked to neurodegeneration.
  • PNNs play crucial roles in CNS function and plasticity.

Purpose of the Study:

  • To review omics technologies applied to perineuronal net (PNN) research.
  • To summarize PNN alterations in the context of neurodegenerative diseases (NDs).
  • To highlight the potential of PNN research for understanding ND pathogenesis and developing therapeutic targets.

Main Methods:

  • Literature review of omics technologies (e.g., genomics, proteomics, metabolomics) applied to PNNs.
  • Analysis of studies reporting PNN structural and functional changes in NDs.
  • Synthesis of findings linking PNNs to disease mechanisms.

Main Results:

  • Omics technologies provide powerful tools for PNN characterization.
  • Specific PNN components and structures are altered in various NDs.
  • These alterations correlate with disease progression and severity.

Conclusions:

  • Omics-based PNN research offers insights into ND pathogenesis.
  • PNNs represent promising targets for novel diagnostic and therapeutic strategies in NDs.
  • Further investigation into PNNs is crucial for advancing treatments for neurodegenerative disorders.