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Updated: Sep 17, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Sickle Cell Disease
Lauren V Ready1, Mary Carroll Lee2, John C Perkins3
1Department of Emergency Medicine, Oregon Health Sciences University, Portland, OR, USA.
None:
Despite advances in outpatient treatment options, early mortality, chronic pain, and limitations in quality-of-life indices remain substantial for those living with SCD. It is imperative for emergency providers (EPs) to understand their challenging and dual obligation when treating a patient with SCD. First, the EP must aggressively manage the acute pain episode in an objective manner. Secondly, it is equally important to consider concurrent pathology that cannot be missed, such as AChS, pulmonary embolism, sepsis, and splenic sequestration. Finally, the EP should prioritize compassionate care that avoids reinforcing any stigma associated with SCD with subsequent detriment to the patient.
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