Related Experiment Video
Updated: Sep 17, 2025
A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
Monitoring the nicotine delivery stability in electronic cigarettes based on in-situ AS/SRD/FOS technology
Shuai Yuan1, Shihao Sun1, Ruilin Qin2
1Beijing Life Science Academy, Beijing, 102299, China; Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, 450001, China.
Background:
It is well known that e-cigarette regulations can be developed with the aid of focusing on nicotine flux (NF) and nicotine delivery stability (NDS), which are defined as the amount of nicotine released per puff under given conditions (vape + recipe). In this study, a convenient and fully automated puff-by-puff aerosol nicotine flux measurement method was developed by combining automatic smoking, spectroscopic rapid detection and fiber-optic sensing (AS/SRD/FOS) technology. Aerosol generated by an e-cigarette was introduced into an "impinger", at the meantime, nicotine was trapped in pure water. After the solution was stable, immediate spectral detection at full wavelength (200-600 nm) was accomplished. Depending on a dual-wavelength method or a coefficient ratio method, the absorption value of nicotine in solution was measured. Finally, nicotine amounts were calculated puff-by-puff.
Results:
The method successfully realized the accurate detection of nicotine flux with low quantification limits (7.1 μg mL-1). Meanwhile, the method has high stability and reproducibility (RSD <10 %), and is suitable for monitoring the NF and NDS.
Significance:
It has great potential for application in the evaluation of nicotine delivery efficiency. It fills the gap in the field of nicotine flux stability measurement and meets the monitoring needs of the industry and quality control for nicotine flux stability of e-cigarettes.
More Related Videos
10:44Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
08:39Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Related Concept Videos
01:29Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...