MR Imaging of Diffuse Peripheral Neuropathy

MR neurography can aid diagnosis and management of diffuse peripheral neuropathies. Diffuse peripheral neuropathies can be due to a variety of causes, including hereditary, inflammatory/autoimmune, infectious, and secondary to systemic conditions, such as diabetes mellitus. MR findings include long-segment (typically more than 6 cm) nerve enlargement and signal hyperintensity and may involve a solitary nerve or multiple nerves, depending on the underlying condition. Importantly, in the interpretation of diffusely abnormal nerves by imaging, neoplastic cause should be ruled out.