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Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Related Experiment Video

Updated: Sep 17, 2025

Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
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MR Imaging of Diffuse Peripheral Neuropathy.

Swati Deshmukh1, Mona Dabiri2, Shivani Ahlawat2

  • 1Department of Radiology, NYU Langone Health, New York University Grossman School of Medicine, 530 First Avenue, New York, NY 10016, USA.

Magnetic Resonance Imaging Clinics of North America
|July 3, 2025
PubMed
Summary

Magnetic Resonance (MR) neurography helps diagnose and manage diffuse peripheral neuropathies. Imaging findings like nerve enlargement and signal changes can indicate various causes, but neoplastic conditions must be excluded.

Keywords:
AIDPCIDPCharcot-Marie-ToothMRNeurographyPeripheral nerve

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Last Updated: Sep 17, 2025

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Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Diffuse peripheral neuropathies stem from diverse etiologies, including hereditary, inflammatory, infectious, and systemic conditions like diabetes mellitus.
  • Accurate diagnosis is crucial for effective management of these neuropathies.

Purpose of the Study:

  • To highlight the role of MR neurography in diagnosing and managing diffuse peripheral neuropathies.
  • To describe characteristic MR imaging findings associated with these conditions.
  • To emphasize the importance of excluding neoplastic causes.

Main Methods:

  • Review of MR neurography findings in patients with diffuse peripheral neuropathies.
  • Correlation of imaging features with clinical and etiological data.
  • Emphasis on specific imaging characteristics such as nerve enlargement and signal intensity.

Main Results:

  • MR neurography reveals characteristic findings such as long-segment (typically >6 cm) nerve enlargement and signal hyperintensity.
  • These findings can be solitary or multifocal, depending on the underlying cause.
  • Imaging findings aid in differentiating various etiologies of diffuse neuropathies.

Conclusions:

  • MR neurography is a valuable tool for the diagnosis and management of diffuse peripheral neuropathies.
  • Characteristic imaging findings can suggest underlying causes, guiding further investigation.
  • Neoplastic processes should be carefully considered and ruled out in the interpretation of diffusely abnormal nerves.