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Updated: Sep 17, 2025

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
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Hedgehog pathway, cell cycle, and primary cilium.

Tenghan Zhuang1,2

  • 1Institute of Veterinary Immunology and Engineering, Jiangsu Academy of Agricultural Sciences, Nanjing, Jiangsu, China. zhuangtenghan@foxmail.com.

Cell Death Discovery
|July 3, 2025
PubMed
Summary
This summary is machine-generated.

The Hedgehog (Hh) pathway is crucial for development and cancer. This review explores its connections with primary cilia and the cell cycle, identifying future research directions.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • The Hedgehog (Hh) signaling pathway is vital for embryonic development and cancer progression.
  • Hh pathway components are integral to primary cilia function.
  • Emerging evidence suggests Hh pathway members also influence cell cycle regulation.

Purpose of the Study:

  • To review recent findings on the interplay between the Hh pathway, primary cilia, and the cell cycle.
  • To highlight potential challenges and opportunities for future research in this area.

Main Methods:

  • Literature review of recent studies.
  • Synthesis of data on Hh pathway, primary cilia, and cell cycle interactions.
  • Identification of emerging research trends and potential pitfalls.

Main Results:

  • The Hh pathway exhibits complex crosstalk with primary cilia and cell cycle machinery.
  • Components of the Hh pathway have roles beyond the cilium, impacting cell division.
  • Understanding these interactions is critical for both developmental processes and cancer therapy.

Conclusions:

  • The Hh pathway's multifaceted roles necessitate a comprehensive understanding of its integration with cilia and cell cycle.
  • Further research is needed to elucidate the precise mechanisms of this crosstalk and its therapeutic implications in tumorigenesis.