Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

5.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic Task Analysis Reveals Distinct Metabotypes in End-Stage Dilated Cardiomyopathy.

Circulation. Genomic and precision medicine·2026
Same author

Resolution Biology in Soft Tissue Joint Disease.

Current topics in microbiology and immunology·2026
Same author

Thermo-mobility coupling: continuous knee temperature-step interaction patterns predict functional recovery after total knee arthroplasty.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie·2026
Same author

GNAQ Induces Melanomagenesis in Mitfa-Independent Melanocyte Progenitors in a Zebrafish Model of Uveal Melanoma.

Cancer research·2026
Same author

Human haematopoietic stem cells remember inflammatory stress.

Nature·2026
Same author

A Health Beliefs Model of Long-Term Prescription Opioid Use for Chronic Pain.

Pain practice : the official journal of World Institute of Pain·2026
Same journal

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.

Nature genetics·2026
Same journal

Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans.

Nature genetics·2026
Same journal

Building up pangenome analysis block by block.

Nature genetics·2026
Same journal

Mutations in splicing factor gene U2AF1 rescue defective oncogene splicing in KRAS-mutant cancers.

Nature genetics·2026
Same journal

Assessing the effect of immune surveillance on clonal expansions in the blood.

Nature genetics·2026
Same journal

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML.

Nature genetics·2026
See all related articles

Related Experiment Video

Updated: Sep 17, 2025

Enumeration of Neural Stem Cells Using Clonal Assays
10:32

Enumeration of Neural Stem Cells Using Clonal Assays

Published on: October 4, 2016

8.4K

Detecting and quantifying clonal selection in somatic stem cells.

Verena Körber1,2, Niels Asger Jakobsen3, Naser Ansari-Pour3,4

  • 1Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany. verena.korber@ndcls.ox.ac.uk.

Nature Genetics
|July 3, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed SCIFER, a method to detect genetic selection in stem cells within tissues like bone marrow and brain. This tool helps understand how selected clones emerge and grow, offering insights into tissue aging and disease risk.

More Related Videos

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

8.7K
Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

7.5K

Related Experiment Videos

Last Updated: Sep 17, 2025

Enumeration of Neural Stem Cells Using Clonal Assays
10:32

Enumeration of Neural Stem Cells Using Clonal Assays

Published on: October 4, 2016

8.4K
Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
09:32

Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture

Published on: May 8, 2018

8.7K
Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

7.5K

Area of Science:

  • Somatic cell genetics
  • Stem cell biology
  • Computational biology

Background:

  • Accumulation of DNA variants in somatic stem cells can alter tissue function.
  • The mechanisms and timing of selection in homeostatic tissues remain poorly understood.
  • Detecting selection in non-malignant tissues is crucial for understanding aging and disease initiation.

Purpose of the Study:

  • To introduce SCIFER, a scalable computational method for identifying genetic selection in individual tissues.
  • To infer stem cell dynamics, clone size, and age without prior knowledge of driver events.
  • To analyze selection patterns in human bone marrow and brain tissues.

Main Methods:

  • Development of SCIFER, a scalable computational method.
  • Application of SCIFER to bulk whole-genome sequencing data from nonmalignant human bone marrow and brain.
  • Analysis of DNA variant accumulation, selection, and clone dynamics in stem cell populations.

Main Results:

  • Pervasive genetic selection was detected in both human bone marrow and brain tissues.
  • Selected clones in hematopoiesis initiated uniformly throughout life, regardless of known drivers.
  • Selected clones in the brain, including pre-malignant ones, originated predominantly in early life (childhood to young adulthood).

Conclusions:

  • SCIFER is a broadly applicable tool for detecting and quantifying selection in renewing somatic tissues.
  • Selection in human tissues occurs dynamically and varies between tissue types (e.g., bone marrow vs. brain).
  • Understanding selection dynamics is key to comprehending tissue homeostasis, aging, and the early stages of diseases like glioma.